·Ç·²¹ú¼Ê,Ö§Á´¾ÛÒÒ¶þ´¼ÑÜÉúÎï,Ö±Á´¾ÛÒÒ¶þ´¼ÑÜÉúÎï-ÆäËü"> ·Ç·²¹ú¼Ê,Ö§Á´¾ÛÒÒ¶þ´¼ÑÜÉúÎï,Ö±Á´¾ÛÒÒ¶þ´¼ÑÜÉúÎï ·Ç·²¹ú¼ÊÊÇ2001Äê10ÔÂ×¢²á½¨ÉèµÄÖÂÁ¦ÓÚÒ½ÓÃÒ©ÓþÛÒÒ¶þ´¼ÑÜÉúÎ﹤ҵ»¯µÄ¸ßÐÂÊÖÒÕÆóÒµ£¬£¬£¬£¬ £¬£¬ £¬£¬×¢²áÓÚ±±¾©Êк£µíÇø¡£¡£¡£¡£¡£¡£¡£"> ·Ç·²¹ú¼Ê,Ö§Á´¾ÛÒÒ¶þ´¼ÑÜÉúÎï,Ö±Á´¾ÛÒÒ¶þ´¼ÑÜÉúÎï"> ·Ç·²¹ú¼Ê,Ö§Á´¾ÛÒÒ¶þ´¼ÑÜÉúÎï,Ö±Á´¾ÛÒÒ¶þ´¼ÑÜÉúÎï-ÆäËü"> ·Ç·²¹ú¼Ê,Ö§Á´¾ÛÒÒ¶þ´¼ÑÜÉúÎï,Ö±Á´¾ÛÒÒ¶þ´¼ÑÜÉúÎï ·Ç·²¹ú¼ÊÊÇ2001Äê10ÔÂ×¢²á½¨ÉèµÄÖÂÁ¦ÓÚÒ½ÓÃÒ©ÓþÛÒÒ¶þ´¼ÑÜÉúÎ﹤ҵ»¯µÄ¸ßÐÂÊÖÒÕÆóÒµ£¬£¬£¬£¬ £¬£¬ £¬£¬×¢²áÓÚ±±¾©Êк£µíÇø¡£¡£¡£¡£¡£¡£¡£">

·Ç·²¹ú¼Ê

LNPsµÝËÍϵͳ¸¨ÁÏ

¾ÛÒÒ¶þ´¼Ö¬ÖÊÊÇLNPsµÝËÍϵͳµÄÖ÷ÒªÒòËØÖ®Ò»
·Ç·²¹ú¼Ê¿Æ¼¼¿ÉÌṩLNPsµÝËÍϵͳ¸¨ÁϵÄʵÑéÊÒÓëGMP¼¶±ð²úÆ·

Ïàʶ¸ü¶à
רҵÌṩPEGÑÜÉúÎïÓëPEG»¯·þÎñ

·Ç·²¹ú¼Ê¿Æ¼¼µÄ²úƷΪÄúÌá¸ßºÍ¸ÄÉÆÒ©ÐÔ
Ϊ¿Í»§Ìṩ´ÓºòÑ¡Ò©Îïɸѡµ½É걨ÁÙ´²Ñо¿µÄÈ«Àú³Ì·þÎñ

Ïàʶ¸ü¶à
/˿õ¹å

ÖйúÊ׿î¾ÛÒÒ¶þ´¼Í¸Ã÷ÖÊËáÄÆÄý½º

Ïàʶ¸ü¶à
ÒÔÖÊÁÏÁ¢ÒìÒýÁìÉúÎïÒ½Ò©Á¢Òì

·Ç·²¹ú¼Ê¿Æ¼¼Í¨¹ýÁËISO13485ÈÏÖ¤
×ñÕÕICHQ7ºÍcGMP ×¼Ôò
ƾ֤¹ú¼ÊcGMP±ê×¼Éú²ú¾ÛÒÒ¶þ´¼ÑÜÉúÎïµÄ¹æÄ£»£»£»£» £»£»£»¯Éú²úÉÌ

Ïàʶ¸ü¶à
PEGÅþÁ¬×Ó

·Ç·²¹ú¼Ê¿Æ¼¼×¨×¢ÓÚPROTAC LinkerµÄÑз¢
PEGÊÇPROTAC¿ª·¢ÖÐ×î³£ÓõÄlinker
·Ç·²¹ú¼Ê¿Æ¼¼Ìṩ¾ßÓÐÖÖÖÖ»îÐÔ»ùÍŵĸߴ¿¶ÈPEG linker

Ïàʶ¸ü¶à
scroll down

COMPANY

·Ç·²¹ú¼Ê

·Ç·²¹ú¼Ê£¨Ö¤È¯´úÂë688356£¬£¬£¬£¬ £¬£¬ £¬£¬Ö¤È¯¼ò³Æ·Ç·²¹ú¼Ê¿Æ¼¼£©ÊÇ2001Äê10ÔÂ×¢²á½¨ÉèµÄÖÂÁ¦ÓÚÒ½ÓÃÒ©ÓþÛÒÒ¶þ´¼ÑÜÉúÎ﹤ҵ»¯µÄ¸ßÐÂÊÖÒÕÆóÒµ£¬£¬£¬£¬ £¬£¬ £¬£¬×¢²áÓÚ±±¾©Êк£µíÇø¡£¡£¡£¡£¡£¡£¡£

2001 ×¢²á½¨ÉèÓÚ
15000 Ìì½ò¹¤Òµ»¯»ùµØÕ¼µØ
1200 ·þÎñº£ÄÚÍâ¿Í»§
600 ²úƷĿ¼ͨÀý²úÆ·
Ïàʶ¸ü¶à

²úÆ·ÖÖÀà

¾ÛÒÒ¶þ´¼ÊÇÎÞζ¡¢µÍ¶¾¡¢µÍÃâÒßÔ­ÐÔ£¬£¬£¬£¬ £¬£¬ £¬£¬¾ßÓÐÓÅÒìµÄË®ÈÜÐÔ¼°ÉúÎïÏàÈÝÐÔ£¬£¬£¬£¬ £¬£¬ £¬£¬Ò½ÓÃÒ©ÓúϳÉÀà¸ß·Ö×ÓÖÊÁÏ£¬£¬£¬£¬ £¬£¬ £¬£¬ÊÇFDAÅú×¼µÄ¿ÉÓÃÓÚÈËÌå×¢ÉäµÄºÏ³ÉÀà¸ß·Ö×Ó¾ÛºÏÎï¡£¡£¡£¡£¡£¡£¡£¾ÛÒÒ¶þ´¼ÐÞÊÎÊÖÒÕÒ²½Ð¾ÛÒÒ¶þ´¼»¯£¨PEGylation£©ÊÇÏÖÔÚС·Ö×ÓÀà¡¢ÂÑ°×ÀàÒÔ¼°¶àëÄÀàÒ©ÎïÆÕ±é½ÓÄɵÄÒ»ÖÖÐÞÊÎÊÖÒÕ¡£¡£¡£¡£¡£¡£¡£½«¾ÛÒÒ¶þ´¼ÑÜÉúÎïżÁªµ½Ò©Îï·Ö×ÓÍâòʱ¿ÉÔöÇ¿Ò©Îï·Ö×ÓµÄË®ÈÜÐÔ¡¢Ê¹ÓþÛÒÒ¶þ´¼µÄÈáÐÔÁ´¶ÎµÄλ×è×÷ÓÿÉΪҩÎï·Ö×ÓÐγɿռäÆÁÕÏ´Ó¶øïÔ̭ø½â£¬£¬£¬£¬ £¬£¬ £¬£¬ÑÓÉìÒ©ÎïÔÚÌåÄڵİëË¥ÆÚ£¬£¬£¬£¬ £¬£¬ £¬£¬½µµÍÒ©ÎïµÄ¶¾¸±×÷ÓúÍÃâÒßÔ­ÐÔ£¬£¬£¬£¬ £¬£¬ £¬£¬¸Ä±äÒ©ÎïÔÚ×éÖ¯ÖÐÂþÑÜÌá¸ß°ÐÏò²¿Î»Å¨¶ÈµÈÍ»³öÓŵ㡣¡£¡£¡£¡£¡£¡£ÏÖÔÚ¾ÛÒÒ¶þ´¼Òѱ»ÆÕ±éÓ¦ÓÃÓÚС·Ö×Ó¡¢ëÄÀà¡¢ÂÑ°×ÖÊ¡¢¿¹ÌåÒÔ¼°ºËËáÀàÒ©ÎïµÄÓ¦ÓÃÖС£¡£¡£¡£¡£¡£¡£Í¬Ê±£¬£¬£¬£¬ £¬£¬ £¬£¬Òò¾ÛÒÒ¶þ´¼ÑÜÉúÎï¾ßÓÐÓÅÁ¼µÄÉúÎïÏàÈÝÐÔºÍÇ×Ë®ÐÔÄÜ£¬£¬£¬£¬ £¬£¬ £¬£¬Ò²±»ÆÕ±éÓ¦ÓÃÓÚǶ¶Î¹²¾ÛÎïÖС£¡£¡£¡£¡£¡£¡£

ÏàʶÏêÇé +

µ¥ÊèÉ¢¾ÛÒÒ¶þ´¼ÑÜÉúÎïÊǾßÓÐÈ·¶¨·Ö×ÓÁ¿¼°½á¹¹µÄµ¥·Ö×ÓÁ¿¾ÛÒÒ¶þ´¼»¯ºÏÎï¡£¡£¡£¡£¡£¡£¡£Æä±£´æÁ˹Űå¾ÛÒÒ¶þ´¼²úÆ·µÄÌصãÖ®Í⣬£¬£¬£¬ £¬£¬ £¬£¬ÓÖÔöÌíÁË´¿¶È¸ß¡¢Åú´Î¿ÉÖظ´ÐÔµÄÓŵ㡣¡£¡£¡£¡£¡£¡£·Ç·²¹ú¼Ê¿Æ¼¼ÓµÓÐÖƱ¸¸ß´¿¶È¼òµ¥·Ö×ÓÁ¿¾ÛÒÒ¶þ´¼¹æÄ£»£»£»£» £»£»£»¯Éú²úµÄÄÜÁ¦£¬£¬£¬£¬ £¬£¬ £¬£¬ÌṩGMP¼°·ÇGMP¼¶±ðµÄÖÊÁÏÓëÑÜÉúÎï²úÆ·£¬£¬£¬£¬ £¬£¬ £¬£¬µ¥Åú´Î×î´ó²úÁ¿¿É´ï10¹«½ï£¬£¬£¬£¬ £¬£¬ £¬£¬·Ö×ÓÁ¿×î¸ß¿É´ï5000 Da¡£¡£¡£¡£¡£¡£¡£

ÏàʶÏêÇé +

µã»÷·´Ó¦ÊÇÒ»Àà¾ßÓж¨Á¿¡¢¿ìËÙ¡¢¸ßЧ¡¢Á¢ÌåÑ¡ÔñÐÔ¡¢ºÜÉÙÉõÖÁûÓи±²úÆ·ÌìÉú¡¢·´Ó¦Ìõ¼þÎÂ˳µÈÌصãµÄ»¯Ñ§·´Ó¦¡£¡£¡£¡£¡£¡£¡£µã»÷»¯Ñ§ÔÚÖÆÒ©ºÍÉúÎïÊÖÒÕÐÐÒµµÄÉúÎïżÁªÓ¦ÓÃÖоßÓÐÆÕ±éµÄÓ¦Óᣡ£¡£¡£¡£¡£¡£

ÏàʶÏêÇé +

Ö¬ÖÊÄÉÃ׿ÅÁ£(Lipid nanoparticles£¬£¬£¬£¬ £¬£¬ £¬£¬LNPs)¼´LNPsµÝËÍϵͳ£¬£¬£¬£¬ £¬£¬ £¬£¬ÆäµÝËÍ»úÖÆͨ³£±»ÒÔΪÊÇLNPͨ¹ý·Ç¹²¼ÛÇ׺ÍÁ¦ºÍϸ°ûĤÍŽᲢͨ¹ýÄÚÍÌ×÷Óñ»Ï¸°ûÉãÈ¡£¡£¡£¡£¡£¡£¡£¬£¬£¬£¬ £¬£¬ £¬£¬½øÈëϸ°ûºómRNA»òsiRNA´ÓÄÚÔÚÌåÌÓÒݵ½Ï¸°ûÖÊÖÐÊ©Õ¹×÷Óᣡ£¡£¡£¡£¡£¡£ LNPsͨ³£ÓÉËÄÖÖÖ÷ÒªÒòËØ×é³É£ºÑôÀë×Ó»ò¿ÉµçÀëµÄÖ¬ÖÊ(Óë´ø¸ºµçºÉµÄÒÅ´«ÎïÖʸ´ºÏ£¬£¬£¬£¬ £¬£¬ £¬£¬ÓÐÖúÓÚÄÚÔÚÌåÌÓÒÝ)¡¢Á×Ö¬(¿ÅÁ£½á¹¹)¡¢µ¨¹Ì´¼(ÓÐÖúÓÚÎȹÌÐÔºÍĤÈÚºÏ)¡¢¾ÛÒÒ¶þ´¼Ö¬ÖÊ(Ìá¸ßÎȹÌÐÔºÍÑ­»·)¡£¡£¡£¡£¡£¡£¡£ ÏÖÔÚ£¬£¬£¬£¬ £¬£¬ £¬£¬Moderna¡¢CureVac¡¢BioNTech£¬£¬£¬£¬ £¬£¬ £¬£¬¾ù½ÓÄÉÖ¬ÖÊÄÉÃ×ÊÖÒÕµÝËÍ(LNP)£¬£¬£¬£¬ £¬£¬ £¬£¬ÕâÒ²Êǵ±ÏÂÔÚºËËáÒ©ÎïÁìÓòÓ¦ÓýÏÁ¿ÆÕ±éµÄµÝËÍÊÖÒÕÀàÐÍ¡£¡£¡£¡£¡£¡£¡£ ·Ç·²¹ú¼Ê¿Æ¼¼¿ÉÌṩLNPsµÝËÍϵͳ¸¨ÁϵÄʵÑéÊÒÓëGMP¼¶±ð²úÆ·¡£¡£¡£¡£¡£¡£¡£·Ç·²¹ú¼Ê¿Æ¼¼ÒÑÓÐ4¸öLNPµÝËÍϵͳ×é·Ö²úÆ·»ñµÃÁËÒ©Óø¨ÁϹҺţ¬£¬£¬£¬ £¬£¬ £¬£¬»®·ÖÊÇM-DTDAM-2000 (ALC-0159£¬£¬£¬£¬ £¬£¬ £¬£¬¹ÒºÅºÅ£º20210000577)¡¢ALC-0315£¨¹ÒºÅºÅ£º20210000466)¡¢M-DMG-2000£¨¹ÒºÅºÅ£º20210000376£©ÓëSM-102£¨¹ÒºÅºÅ£º20220000268£©£¬£¬£¬£¬ £¬£¬ £¬£¬ÉÐÓÐÆäËûDMFÊÂÇéÕýÔÚ´òµãÖС£¡£¡£¡£¡£¡£¡£¹«Ë¾³Ð¼Ì¡°ÒÔÖÊÁÏÁ¢ÒìÒýÁìÉúÎïÒ½Ò©Á¢Ò족µÄ×ÚÖ¼£¬£¬£¬£¬ £¬£¬ £¬£¬×¢ÖØÊÖÒÕÑз¢£¬£¬£¬£¬ £¬£¬ £¬£¬ÈçÄúÐèÒªÆäËüδÁгöµÄ½á¹¹£¬£¬£¬£¬ £¬£¬ £¬£¬»¶Ó­ÄúÀ´µç×Éѯ£¬£¬£¬£¬ £¬£¬ £¬£¬·Ç·²¹ú¼Ê¿Æ¼¼»áΪÄúÌṩ¶¨ÖƺϳɷþÎñ£¬£¬£¬£¬ £¬£¬ £¬£¬ÎªÄúµÄÑз¢ÏîÄ¿Ìṩȫ·½Î»Ö§³Ö·þÎñ¡£¡£¡£¡£¡£¡£¡£

ÏàʶÏêÇé +

·Ç·²¹ú¼Ê¿Æ¼¼µÄ²úƷΪÄúÌá¸ßºÍ¸ÄÉÆÒ©ÐÔ£¬£¬£¬£¬ £¬£¬ £¬£¬Îª¿Í»§Ìṩ´ÓºòÑ¡Ò©Îïɸѡµ½É걨ÁÙ´²Ñо¿µÄÈ«Àú³Ì·þÎñ£¡

ÏàʶÏêÇé +

·Ç·²¹ú¼Ê¿Æ¼¼µÄ²úƷΪÄúÌá¸ßºÍ¸ÄÉÆÒ©ÐÔ£¬£¬£¬£¬ £¬£¬ £¬£¬Îª¿Í»§Ìṩ´ÓºòÑ¡Ò©Îïɸѡµ½É걨ÁÙ´²Ñо¿µÄÈ«Àú³Ì·þÎñ£¡

ÏàʶÏêÇé +

Äý½ºÉø͸ɫÆ×£¨GPC£©·¨²â¶¨´ó·Ö×Ó¾ÛºÏÎïµÄ·Ö×ÓÁ¿ºÍ¶àÊèÉ¢¶È£¬£¬£¬£¬ £¬£¬ £¬£¬¾ßÓвÙ×÷¼òÆÓ£¬£¬£¬£¬ £¬£¬ £¬£¬¾­¼Ã¿ìËÙµÈÓŵ㣬£¬£¬£¬ £¬£¬ £¬£¬Òò´ËÔÚ¸÷ÐÐÒµ»ñµÃÆÕ±éµÄʹÓᣡ£¡£¡£¡£¡£¡£¹ØÓÚÕâÖÖÒªÁìÀ´Ëµ£¬£¬£¬£¬ £¬£¬ £¬£¬Ôڲⶨ´ý²âÑùƷʱ£¬£¬£¬£¬ £¬£¬ £¬£¬ÐèҪѡÔñ±ê׼ƷÀ´×ö±ê×¼ÇúÏߣ¬£¬£¬£¬ £¬£¬ £¬£¬Òò´Ë¹ØÓÚ׼ȷ²â¶¨¸ß·Ö×Ó¾ÛºÏÎïµÄ·Ö×ÓÁ¿À´Ëµ£¬£¬£¬£¬ £¬£¬ £¬£¬±ê׼ƷµÄ׼ȷѡÔñ¾ÍÏÔµÃÓÈΪÖ÷Òª¡£¡£¡£¡£¡£¡£¡£

ÏàʶÏêÇé +

·Ç·²¹ú¼Ê¿Æ¼¼µÄ²úƷΪÄúÌá¸ßºÍ¸ÄÉÆÒ©ÐÔ£¬£¬£¬£¬ £¬£¬ £¬£¬Îª¿Í»§Ìṩ´ÓºòÑ¡Ò©Îïɸѡµ½É걨ÁÙ´²Ñо¿µÄÈ«Àú³Ì·þÎñ£¡

ÏàʶÏêÇé +

SERVICE

ÊÖÒÕ·þÎñ

·Ç·²¹ú¼Ê¿Æ¼¼ÔÚ¾ÛÒÒ¶þ´¼»¯ÁÙ´²Ç°½×¶ÎµÄ¾ÛÒÒ¶þ´¼»¯·þÎñºÍ¾ÛÒÒ¶þ´¼»¯Å¼ÁªÎïµÄ¶¨Öƺϳɷ½Ãæ¾ßÓи»ºñÂÄÀú£¬£¬£¬£¬ £¬£¬ £¬£¬¿ÉÖª×ã¿Í»§¶ÔÂÑ°×ÖÊ¡¢ëÄ¡¢¹ÑºËÜÕËáºÍС·Ö×ÓµÈÖÖÖÖÒ©ÎïµÄÆæÒì¾ÛÒÒ¶þ´¼»¯ÐèÇ󡣡£¡£¡£¡£¡£¡£

ÏàʶÏêÇé
·Ç·²¹ú¼Ê¿Æ¼¼Ê¹ÓÃÊýÊ®ÄêÔÚÑо¿¡¢¿ª·¢ºÍÖÆÔìÁ¢ÒìµÄPEGÑÜÉúÎï¡¢PEG¹²¾ÛÎïºÍ¾ÛÒÒ¶þ´¼»¯Å¼ÁªÎï·½ÃæµÄרҵ֪ʶ£¬£¬£¬£¬ £¬£¬ £¬£¬Ìṩ¶¨ÖÆ»¯PEGºÏ³É·þÎñ¡£¡£¡£¡£¡£¡£¡£

·Ç·²¹ú¼Ê¿Æ¼¼¿ÉÒÔΪ¿Í»§ÌṩÍêÕûµÄ¾ÛÒÒ¶þ´¼»¯ÒªÁ쿪·¢·þÎñ¡£¡£¡£¡£¡£¡£¡£Æ¾Ö¤¿Í»§µÄÏîÄ¿ÐèÇ󣬣¬£¬£¬ £¬£¬ £¬£¬·Ç·²¹ú¼ÊµÄ¾ÛÒÒ¶þ´¼»¯ÍŶӿÉÒÔΪ¿Í»§È·¶¨ºÏÊʵĸßÖÊÁ¿¾ÛÒÒ¶þ´¼ÑÜÉúÎ£¬£¬£¬ £¬£¬ £¬£¬²¢Ìṩ¾ÛÒÒ¶þ´¼»¯ÑùÆ·ÒÔ¼°ÍêÕûµÄÒªÁ쿪·¢Îļþ£¬£¬£¬£¬ £¬£¬ £¬£¬°üÀ¨Îª¿Í»§µÄ¾ÛÒÒ¶þ´¼»¯²úÆ·¶¨ÖÆ¿ª·¢µÄÆÊÎöÒªÁ죬£¬£¬£¬ £¬£¬ £¬£¬È«·½Î»Ö§³Ö¿Í»§´ÓÔçÆÚ¾ÛÒÒ¶þ´¼ÑÜÉúÎïÊÔ¼ÁɸѡֱÖÁÁÙ´²Ç°½×¶ÎµÄÐèÇ󡣡£¡£¡£¡£¡£¡£

·Ç·²¹ú¼Ê¿Æ¼¼ÒÀ¸½¶Ô¾ÛÒÒ¶þ´¼¼°Æä»îÐÔÑÜÉúÎïµÄÉî¿ÌÃ÷È·£¬£¬£¬£¬ £¬£¬ £¬£¬×ÔÖ÷Ñз¢È¡µÃÏà¹ØרÀû¡¢ÁÙ´²ÊÔÑéÅú¼þµÈ֪ʶ²úȨºó¾ÙÐÐÔÊÐí»òתÈᣡ£¡£¡£¡£¡£¡£

·Ç·²¹ú¼Ê¿Æ¼¼¿ÉЭÖú¿Í»§Íê³ÉÓëÖÊÁÏÏà¹ØµÄÖÖÖÖÁÙ´²Ç°ÐëÒªÑо¿£¬£¬£¬£¬ £¬£¬ £¬£¬²¢¾ÙÐÐINDÉ걨¡£¡£¡£¡£¡£¡£¡£

ÐÂÎŶ¯Ì¬

Éç»áÔðÈÎ

ÇéÐÎÔðÈÎ

ÂÌË®Çàɽ¾ÍÊǽðɽÒøɽ”£¬£¬£¬£¬ £¬£¬ £¬£¬½«ÂÌÉ«ÀíÄîÂäʵµ½´ÓÑз¢µ½Éú²úµÄ¸÷¸ö·½Ã棬£¬£¬£¬ £¬£¬ £¬£¬±£»£»£»£» £»£»£»¤ÎÒÃÇÅäºÏµÄ¼ÒÔ°

Éç»áÔðÈÎ

¼á³ÖרÐÄ×öºÃÆóÒµ¡¢Óð®»ØÀ¡Éç»á£¬£¬£¬£¬ £¬£¬ £¬£¬Ò»Á¬¹ØעǷÅµØÇø¼°Éç»áÈõÊÆȺÌåµÄ¿µ½¡ÓëÉú³¤

ÖÎÀíÔðÈÎ

·Ç·²¹ú¼Ê¿Æ¼¼¸ßÖÊÁ¿¼ùÐÐÂÌÉ«Éú³¤ÀíÄ£¬£¬£¬ £¬£¬ £¬£¬ÀÖ³Éͨ¹ýÌì½òÊй¤ÒµºÍÐÅÏ¢»¯¾ÖÉóºË£¬£¬£¬£¬ £¬£¬ £¬£¬±»ÕýʽÈ϶¨Îª2022Äê¶ÈÌì½òÊÐÂÌÉ«¹¤³§¡£¡£¡£¡£¡£¡£¡£

ÍøÕ¾µØͼ
ÓÑÇéÁ´½Ó£ºÓÅ¿á  ÑëÊÓ  ÈËÈËÍø  QQÒôÀÖ  ¶«·½²Æ¸»  4399СÓÎÏ·